Adenovirus type 12 gene 401 function in transforming infection
نویسندگان
چکیده
منابع مشابه
Structure and function of adenovirus type 12 defective virions.
Purified human adenovirus type 12 preparations contain defective virions with a lighter density. These defective virions were isolated, and their biological functions and DNA were characterized. They can induce early and late antigens in infected cells and tumors in newborn hamsters with similar efficiency as complete virions. The majority of the DNA molecules from light virions contain deletio...
متن کاملFunction of simian virus 40 gene A in transforming infection.
In productive infection by simian virus 40, the A gene is known to regulate the initiation of viral DNA replication and to control the synthesis of late viral RNA. The function of the A gene in transforming infection was investigated by the infection of a variety of cell species with six independently isolated temperature-sensitive mutants belonging to the A complementation group. The A mutants...
متن کاملAntigenic Variation Among Adenovirus Type 12 Strains.
Recent reports relative to the oncogenicity of adenovirus types 12 and 18 (Trentin, Yabe, and Taylor, Science 137:835, 1962; Huebner, Rowe, and Lane, Proc. Natl. Acad. Sci. U.S. 48:2051, 1962) have caused a renewed surge of interest in the adenovirus group. In addition to the prototype strain Huie, Huebner and co-workers investigated eight adenovirus type 12 strains, recovered from anal swabs o...
متن کاملAdenovirus type 12-rat embryo transformation system.
Adenovirus type 12 (Huie) inoculated into cultures of primary whole rat embryo produced foci of morphologically altered cells. The number and identification of these transformed areas was dependent upon the calcium concentration of the medium; more foci appeared in 0.1 mm than in 1.8 mm calcium. Cell lines derived from these inoculated cultures did not yield infectious virus, and also were simi...
متن کاملActivation of the human beta interferon gene by the adenovirus type 12 E1B gene.
The transcription of endogenous beta interferon mRNA was activated in human embryo kidney (HEK) cells infected with adenovirus type 12 (Ad12) but was activated only inefficiently or not at all in HEK cells infected with Ad5 and rc-1 (Ad5 dl312 containing the Ad12 E1A region). The analysis with Ad12 mutants showed that Ad12 E1B products, especially the 19K protein, were important for the express...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 1978
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.26.3.828-831.1978